Research Library
This library is a reference point for the science behind the six SEQUENCE research categories. Each entry covers the mechanisms researchers study, the compounds associated with that area, and the questions active in the field. All compounds supplied by SEQUENCE are intended for laboratory and in-vitro research only.
How to use this library
Each category maps a biological domain to the peptides researchers use to study it. The entries describe mechanisms as they appear in peer-reviewed literature — not outcomes, not protocols, not recommendations. If you are a researcher looking for a starting point, the citations linked within each section will take you to the primary sources.
SEQUENCE does not provide research advice or study design guidance. For questions about compound specifications, purity certificates, or ordering, contact us directly.
The six research categories
REPAIR
Structural recovery · Gut health · Inflammation modulation
The REPAIR category covers three interconnected areas of tissue research: the structural integrity of connective tissue, the barrier function of the gut wall, and the inflammatory signalling that runs through both.
Structural recovery is the focus of research into peptides that interact with extracellular matrix remodelling. Studies in this area examine how synthetic peptides influence fibroblast behaviour, collagen cross-linking, and the speed and quality of tissue repair following mechanical stress or injury.
Gut wall and barrier function is an active area of research examining how the epithelial lining of the gastrointestinal tract maintains selective permeability. Researchers study peptides that appear to modulate tight junction proteins, which regulate what passes between gut cells and enters systemic circulation.
Managing the inflammation response is a broad field covering the cytokine cascades and signalling pathways that drive acute and chronic inflammatory states. Research in this domain looks at how certain peptide sequences interact with known inflammatory mediators at a molecular level.
Compounds associated with REPAIR research: BPC-157, TB-500 (Thymosin Beta-4 fragment)
REGENERATE
Collagen synthesis · Copper remodelling · Antioxidant recycling
The REGENERATE category covers research into the structural proteins and trace-element systems that maintain tissue quality over time.
Collagen synthesis research examines the multi-step process by which the body produces and organises collagen fibres. Studies look at how peptide sequences derived from collagen precursors influence the rate and type of collagen produced in dermal and connective tissue cell cultures.
Copper remodelling is studied through copper-binding peptide complexes, which researchers use to examine copper transport and utilisation in skin and vascular tissue. Copper is a cofactor in several enzymes involved in cross-linking collagen and elastin, making it relevant to studies of structural tissue integrity.
Antioxidant recycling covers the enzymatic pathways that regenerate depleted antioxidants within cells, particularly in tissues under oxidative stress. Research in this area looks at how certain peptides influence the activity of enzymes such as superoxide dismutase and glutathione peroxidase.
Compounds associated with REGENERATE research: GHK-Cu, Epithalon
REVIVE
GH pulse stimulation · Sleep architecture · Body composition
The REVIVE category maps to research on growth hormone secretion, sleep stage regulation, and the relationship between the two in studies of body composition.
Signal body to release growth hormone is the central question in growth hormone secretagogue research. Researchers study how synthetic peptides interact with the ghrelin receptor and the hypothalamic-pituitary axis to influence the pulsatile pattern of GH secretion. This field examines both the amplitude and frequency of GH pulses as measurable endpoints.
Reorganise natural sleep cycle covers research into the delta-wave slow-wave sleep stages where the largest natural GH pulses occur. Certain peptides studied in this category appear to interact with sleep architecture in ways that researchers measure through polysomnography in animal models.
Promote fat loss and retain muscle describes the downstream body composition effects that researchers observe in GH-related studies. This is studied through markers of lipolysis, nitrogen retention, and lean mass in controlled research settings.
Compounds associated with REVIVE research: Ipamorelin, CJC-1295, Tesamorelin
RESOLVE
Insulin sensitivity · Appetite signalling · Energy expenditure
The RESOLVE category covers metabolic research — specifically the signalling pathways that govern how cells respond to glucose, how the brain registers satiety, and how the body determines its rate of energy use.
Insulin sensitivity research examines how cells respond to insulin signalling at the receptor level. Studies look at the downstream effects on glucose uptake and storage, and how certain peptides influence GLUT-4 translocation and other markers of insulin responsiveness in cell culture and animal models.
Appetite signalling covers the hormonal and neuropeptide pathways that communicate satiety between the gut, adipose tissue, and the hypothalamus. Research in this area includes GLP-1 receptor biology, leptin signalling, and the role of gut-derived peptides in regulating food intake.
Energy expenditure refers to the study of metabolic rate and thermogenesis. Researchers examine how peptides influence brown adipose tissue activation, mitochondrial uncoupling, and the overall rate at which cells consume energy substrates.
Compounds associated with RESOLVE research: GLP-2 and GLP-3
REGAIN
Hormone production · Cognitive function · Libido research
The REGAIN category maps to endocrine research centred on the hypothalamic-pituitary-gonadal (HPG) axis and its downstream effects on neurological function and reproductive biology.
Hormone production research in this category focuses on the HPG axis — the cascade of signalling from the hypothalamus through the pituitary to the gonads that governs the production of testosterone, oestrogen, and related hormones. Studies look at how certain peptides interact with gonadotropin-releasing hormone (GnRH) receptors and downstream luteinising hormone (LH) secretion.
Cognitive function is studied in the context of neurosteroid influence on brain function. Testosterone and other gonadal hormones have well-documented receptor activity in the central nervous system, and researchers study how changes in their levels correlate with markers of memory, executive function, and neuroprotection in model systems.
Libido research covers the neurobiological and endocrine mechanisms behind sexual motivation. This includes melanocortin receptor research, which is a distinct pathway from the HPG axis and an active area of study in its own right.
Compounds associated with REGAIN research: Kisspeptin-10, PT-141 (Bremelanotide)
RESTORE
Mitochondrial function · Cellular fuel levels · Epigenetic regulation
The RESTORE category covers research at the cellular energy level — specifically how mitochondria produce and regulate ATP, how NAD+ availability affects that process, and how epigenetic mechanisms influence which energy-related genes are expressed.
Mitochondrial function research examines the efficiency of the electron transport chain and oxidative phosphorylation. Researchers use peptides in this category to study mitochondrial biogenesis — the process by which cells produce new mitochondria — and mitophagy, the clearance of dysfunctional ones.
Cellular fuel levels refers to the study of NAD+ (nicotinamide adenine dinucleotide), a coenzyme central to hundreds of metabolic reactions and a required substrate for sirtuins, a family of proteins involved in cellular stress response and longevity research. Studies examine how NAD+ precursors and related compounds influence cellular NAD+ pools.
Epigenetic regulation covers the mechanisms by which gene expression is controlled without changes to the DNA sequence itself. Sirtuins and other NAD+-dependent enzymes act as epigenetic regulators, and research in this area looks at how they influence chromatin structure and the expression of metabolic genes.
Compounds associated with RESTORE research: Epithalon, MOTS-c, NAD+
A note on research context
The mechanisms described in this library are drawn from in-vitro studies, animal model research, and early-phase human studies available in peer-reviewed literature. The strength and consistency of evidence varies considerably by compound and by endpoint. Researchers are encouraged to review primary sources and assess the evidence independently before designing studies.
Where human studies exist, they are often small, short-term, and not always independently replicated. This library does not weight or rank evidence — it maps the research territory as it currently exists.
All compounds supplied by SEQUENCE are for research use only. Not for human consumption. SEQUENCE does not make any medical claims. Nothing on this page constitutes medical advice, a treatment recommendation, or a health claim of any kind.